I'm a HUGE fan of the Berkson protocol, and truly feel that it saved my husband's life, but I also know that too much ALA can damage the mitochondria (he says so in this interview on THIS PAGE). But this is the study that shows it.
Thought I should post it here. The link is below.
https://www.semanticscholar.org/paper/Adverse-Effects-of-High-Doses-of-Intravenous-Alpha-Vigil-Berkson/b706f02b1a88f58f14dec92421e9dbfdec63bc55
Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
- Published 2014 in Global advances in health and medicine
DOI:10.7453/gahmj.2013.011
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent. LESS
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