For years, I have been a huge fan of Vitamin D, since I found out it practically eliminates back pain. But I never realized it could help treat liver fibrosis, until now.
Here is an article I pasted from this site.
I am not a doctor and can't diagnose anyone else's condition. However I have heard it is OK to consume up to 10,000 IU of Vitamin D3 per day, and recently, after hearing that very high doses can be considered safe, I started taking about 20,000 IU with no adverse effects. A friend of mine suggested doing this, because she did it (was taking about 50,000 IU per day) and was feeling GREAT, but eventually she did find out that there was too much Vitamin D in her blood, and she had to ease up. She is not stopping the Vitamin D, just taking less of it. Also, her husband was having horrible back pain and almost crying in pain, but then he started on the Vitamin D and felt much better. This also happened to other friends of mine.
You can read a book about the miraculous effects that can be achieved by taking very high doses of Vitamin D, by CLICKING HERE.
I can't tell you what to do, but if it was me starting over and I'd never taken it before, I'd start with 10,000 IU per day and see how I feel; then gage if I should start, stop, increase, etc..
Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis
Date:
April 25, 2013
Source:
Salk Institute for Biological Studies
Summary:
Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).
This image shows mouse liver tissue with fibrosis (red), a type of scarring caused by chronic liver diseases and injuries. Salk researchers found that a drug already approved by the FDA for the treatment of psoriasis deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.
Credit: Courtesy of the Salk Institute for Biological Studies
Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).
Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.
"Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment," says senior author Ronald M. Evans, a professor in Salk's Gene Expression Laboratory and lead researcher in the Institute's new Helmsley Center for Genomic Medicine.
The Salk study focused on a star-shaped "stellate" cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases.
The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. "Preclinical results suggest the 'vitamin D brake' is highly efficacious and led us to believe that the time is right to consider a trial in the context of chronic liver disease," says Evans, a Howard Hughes Medical Institute Investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.
Previous studies have shown a physiologic role for vitamin D in liver function, but "it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis," says lead author Ning Ding, a research associate in the Gene Expression Laboratory.
"Current therapeutic approaches, which treat the symptoms of liver disease, don't stop liver fibrosis from progressing," says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and co-corresponding author on the paper. "In liver diseases where the underlying cause cannot be cured, progression to cirrhosis is currently inevitable in some people. What we have discovered is that by acting on the genome, VDR can simultaneously defend against multiple fibrotic activators. This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response."
The Salk discovery that calcipotriol counters the fibrotic response in stellate cells illuminates a potentially safer, more effective strategy capable of neutralizing multiple convergent fibrotic triggers.
The Salk scientists say that clinical trials of the vitamin D analog for the treatment of liver fibrosis are being planned. The synthetic vitamin D analog is better than natural vitamin D, they say, for a couple of reasons. First, natural vitamin D, which is found in small amounts in a few foods and produced in the body by exposure to sunlight, degrades quickly, while synthetic versions of vitamin D are less susceptible to breakdown. Second, too much natural vitamin D can cause hypercalcemia, or elevated calcium in the blood, which can lead to nausea and vomiting, frequent urination, muscle weakness and joint aches and pain. The synthetic vitamin D analog, on the other hand, produces a strong response without adding calcium to the blood.
In addition, the researchers say this new model for treating liver fibrosis may also be helpful in treating other diseases with a fibrotic component, including those of the lung, kidney and pancreas.
Other researchers on the study were Ruth T. Yu, Mara H. Sherman, Mathias Leblanc, Mingxiao He, Annette R. Atkins and Grant D. Barish, from the Salk Institute; Nanthakumar Subramaniam, Caroline Wilson, Renuka Rao, Sally Coulter and Christopher Liddle, of the University of Sydney (Australia); and Sue L. Lau , Christopher Scott and Jenny E. Gunton, of the Garvan Insitute for Medical Research (Australia).
The work was supported by grants from the National Institutes of Health, the Howard Hughes Medical Institute, the National Health and Medical Research Council of Australia, the Genentech Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, Stand Up to Cancer and Ipsen/Biomeasure.
Story Source:
The above story is based on materials provided by Salk Institute for Biological Studies. Note: Materials may be edited for content and length.
CLICK HERE TO FIND AN ALCOHOLICS ANONYMOUS CHAPTER IN YOUR AREA
CLICK ON THESE LINKS FOR MY OTHER POSTS
to learn about:
Please note: I am not a doctor and I am only able to tell you what I have learned by doing my own research on the internet, and share with you the things that have worked for my husband. Please remember that Liver Cirrhosis is a very serious disease so I am not saying, do not see a doctor. Doctors have helped my
husband a lot. But I believe it is wise to do as much research as you can, and find out why
they are giving you every one of the medications and treatments they are giving you.
I believe they do not always know about or understand every treatment option that is available,
and there are many good options out there that can help.
Your health is ultimately your own responsibility, above anyone else's.
Best of luck to you!!!
If you have something to share, please feel free to leave a comment on this blog.
Keywords: healing liver cirrhosis, how to heal liver cirrhosis, cirrhosis cure, AA, alcoholics anonymous, how to beat cirrhosis, how to stop drinking, how i healed liver cirrhosis, heal yourself from liver cirrhosis, how to heal fibrosis, how to reverse cirrhosis, how to reverse fibrosis, cirrhosis cure, cure liver cirrhosis, the cirrhosis bible, book on cirrhosis, best foods to eat for cirrhosis, how to cure cirrhosis of the liver, how to heal cirrhosis of the liver, how to reverse cirrhosis of the liver, how to heal your liver, how to heal my liver, the ezra protocol, end stage cirrhosis, meld score, end stage liver disease, acid reflux, antacids, dangers of proton pump inhibitors, paracentesis, parascentesis, dangers of proton pump inhibitors pantoprazole omeprazole protonix vimovo Protonix Nexium prevacid prilosec Dexilant Aciphex PPi's acid reflux GERD, heartburn, FDA warning
No comments:
Post a Comment